|Other Names||DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|
|Cellular Location||Cytoplasm. Nucleus, nucleolus.|
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This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This nuclear enzyme is involved in processes such aschromosome condensation, chromatid separation, and the relief oftorsional stress that occurs during DNA transcription andreplication. It catalyzes the transient breaking and rejoining oftwo strands of duplex DNA which allows the strands to pass throughone another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. Thegene encoding this form, beta, is localized to chromosome 3 and thealpha form is localized to chromosome 17. The gene encoding thisenzyme functions as the target for several anticancer agents and avariety of mutations in this gene have been associated with thedevelopment of drug resistance. Reduced activity of this enzyme mayalso play a role in ataxia-telangiectasia. Alternative splicing ofthis gene results in two transcript variants; however, the secondvariant has not yet been fully described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ovsyannikova, I.G., et al. Hum. Genet. 127(2):207-221(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Deweese, J.E., et al. Biochemistry 48(9):1862-1869(2009)
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