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TOP2B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q02880 |
|---|---|
| Clone Names | 80722102 |
| Gene ID | 7155 |
|---|---|
| Other Names | DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TOP2B |
|---|---|
| Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus |
| Tissue Location | Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas (PubMed:9155056). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This nuclear enzyme is involved in processes such aschromosome condensation, chromatid separation, and the relief oftorsional stress that occurs during DNA transcription andreplication. It catalyzes the transient breaking and rejoining oftwo strands of duplex DNA which allows the strands to pass throughone another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. Thegene encoding this form, beta, is localized to chromosome 3 and thealpha form is localized to chromosome 17. The gene encoding thisenzyme functions as the target for several anticancer agents and avariety of mutations in this gene have been associated with thedevelopment of drug resistance. Reduced activity of this enzyme mayalso play a role in ataxia-telangiectasia. Alternative splicing ofthis gene results in two transcript variants; however, the secondvariant has not yet been fully described.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ovsyannikova, I.G., et al. Hum. Genet. 127(2):207-221(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Deweese, J.E., et al. Biochemistry 48(9):1862-1869(2009)
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