|Other Names||Zinc finger MYND domain-containing protein 10, Protein BLu, ZMYND10, BLU|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to sites proximal to the axoneme.|
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BLU is a candidate tumor suppressor gene, that spans 4.5 kb on 3p21.3. It encodes a 50 kd protein, which is commonly found in transcription repressors. It is suspected that BLU has a function in cell cycle progression. BLU is a stress-responsive gene regulated by E2F.12 It is commonly found to be downregulated in non-small cell lung cancer, esophagus squamous cell carcinoma and nasopharyngeal carcinoma (NPC).
Shao, Y., et al. Cancer Invest. 28(6):642-648(2010)Lorente, A., et al. Brain Pathol. 19(2):279-292(2009)Muzny, D.M., et al. Nature 440(7088):1194-1198(2006)Marsit, C.J., et al. Int. J. Cancer 114(2):219-223(2005)Qiu, G.H., et al. Oncogene 23(27):4793-4806(2004)
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