|Other Names||Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.|
|Cellular Location||Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity).|
|Tissue Location||Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine|
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GLRX3 is a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Ohayon, A., et al. J. Histochem. Cytochem. 58(9):799-806(2010)Haunhorst, P., et al. Biochem. Biophys. Res. Commun. 394(2):372-376(2010)Ohayon, A., et al. J Immunotoxicol 7(1):8-14(2010)Cha, M.K., et al. Cancer Epidemiol 33 (3-4), 281-287 (2009) :Roeske, D., et al. Mol. Psychiatry (2009) In press :
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