|Other Names||Peroxiredoxin-4, Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, PRDX4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I- kappa-B-alpha phosphorylation.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Note=Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an antioxidant enzymeand belongs to the peroxiredoxin family. The protein is localizedto the cytoplasm. Peroxidases of the peroxiredoxin family reducehydrogen peroxide and alkyl hydroperoxides to water and alcoholwith the use of reducing equivalents derived from thiol-containingdonor molecules. This protein has been found to play a regulatoryrole in the activation of the transcription factor NF-kappaB.
Jamaluddin, M., et al. J. Virol. 84(18):9533-9545(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Edvardsen, H., et al. Pharmacogenomics J. (2010) In press :Wang, H.Q., et al. FEBS Lett. 583(9):1511-1515(2009)Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)
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