|Other Names||E3 ubiquitin-protein ligase TRIM69, 632-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle|
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This gene encodes a member of the RING-B-box-coiled-coil(RBCC) family and encodes a protein with an N-terminal RING fingermotif, a PRY domain and a C-terminal SPRY domain. The mouseortholog of this gene is specifically expressed in germ cells atthe round spermatid stages during spermatogenesis and, whenoverexpressed, induces apoptosis. Alternatively spliced transcriptvariants encoding distinct isoforms have been described. It may play a role in apoptosis (By similarity).
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shyu, H.W., et al. Exp. Cell Res. 287(2):301-313(2003)Shyu, H.W., et al. Mech. Dev. 108 (1-2), 213-216 (2001) :Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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