TRIM69 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86WT6 |
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Clone Names | 100408354 |
Gene ID | 140691 |
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Other Names | E3 ubiquitin-protein ligase TRIM69, 632-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM69 |
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Synonyms | RNF36 |
Function | E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Plays also a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411). |
Cellular Location | Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules |
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Background
This gene encodes a member of the RING-B-box-coiled-coil(RBCC) family and encodes a protein with an N-terminal RING fingermotif, a PRY domain and a C-terminal SPRY domain. The mouseortholog of this gene is specifically expressed in germ cells atthe round spermatid stages during spermatogenesis and, whenoverexpressed, induces apoptosis. Alternatively spliced transcriptvariants encoding distinct isoforms have been described. It may play a role in apoptosis (By similarity).
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shyu, H.W., et al. Exp. Cell Res. 287(2):301-313(2003)Shyu, H.W., et al. Mech. Dev. 108 (1-2), 213-216 (2001) :Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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