|Other Names||Splicing factor 3B subunit 5, SF3b5, Pre-mRNA-splicing factor SF3b 10 kDa subunit, SF3B5, SF3B10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).|
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Provided below are standard protocols that you may find useful for product applications.
The SF3B5 is one of five subunits of the splicing factor 3B.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Will, C.L., et al. RNA 10(6):929-941(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)Zhou, Z., et al. Nature 419(6903):182-185(2002)
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