|Other Names||Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2, SR Ca(2+)-ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, ATP2A2, ATP2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the SERCA Ca(2+)-ATPases, whichare intracellular pumps located in the sarcoplasmic or endoplasmicreticula of muscle cells. This enzyme catalyzes the hydrolysis ofATP coupled with the translocation of calcium from the cytosol intothe sarcoplasmic reticulum lumen, and is involved in regulation ofthe contraction/relaxation cycle. Mutations in this gene causeDarier-White disease, also known as keratosis follicularis, anautosomal dominant skin disorder characterized by loss of adhesionbetween epidermal cells and abnormal keratinization. Alternativesplicing results in multiple transcript variants encoding differentisoforms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Tuusa, J.T., et al. FEBS J. 277(13):2815-2829(2010)Godic, A., et al. Eur J Dermatol 20(3):271-275(2010)Godic, A., et al. J. Am. Acad. Dermatol. 62(5):819-823(2010)Kiec-Wilk, B., et al. Prz. Lek. 67(3):151-156(2010)
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