|Other Names||Protein Wnt-10a, WNT10A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. It isstrongly expressed in the cell lines of promyelocytic leukemia andBurkitt's lymphoma. In addition, it and another family member, theWNT6 gene, are strongly coexpressed in colorectal cancer celllines. The gene overexpression may play key roles in carcinogenesisthrough activation of the WNT-beta-catenin-TCF signaling pathway.This gene and the WNT6 gene are clustered in the chromosome 2q35region.
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)Nawaz, S., et al. Eur. J. Hum. Genet. 17(12):1600-1605(2009)Medland, S.E., et al. Am. J. Hum. Genet. 85(5):750-755(2009)Bohring, A., et al. Am. J. Hum. Genet. 85(1):97-105(2009)
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