|Other Names||CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44, LHR, MDU2, MDU3, MIC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LHR, MDU2, MDU3, MIC4|
|Function||Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.|
|Tissue Location||Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells|
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The protein encoded by this gene is a cell-surfaceglycoprotein involved in cell-cell interactions, cell adhesion andmigration. It is a receptor for hyaluronic acid (HA) and can alsointeract with other ligands, such as osteopontin, collagens, andmatrix metalloproteinases (MMPs). This protein participates in awide variety of cellular functions including lymphocyte activation,recirculation and homing, hematopoiesis, and tumor metastasis.Transcripts for this gene undergo complex alternative splicing thatresults in many functionally distinct isoforms, however, the fulllength nature of some of these variants has not been determined.Alternative splicing is the basis for the structural and functionaldiversity of this protein, and may be related to tumor metastasis.
da Cunha, C.B., et al. Lab. Invest. 90(11):1604-1614(2010)Somasunderam, A., et al. Biochemistry 49(42):9106-9112(2010)Wolny, P.M., et al. J. Biol. Chem. 285(39):30170-30180(2010)Ryckman, K.K., et al. PLoS ONE 5 (8), E12273 (2010) :Scartozzi, M., et al. Anal. Quant. Cytol. Histol. 31(6):417-423(2009)
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