|Other Names||Protein naked cuticle homolog 2, Naked-2, hNkd2, NKD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.|
|Cellular Location||Cell membrane. Cytoplasm. Cytoplasmic vesicle|
|Tissue Location||Expressed in kidney, lung, pancreas and spleen.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM601365)-binding protein that functions as a negative regulator ofthe Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf(see MIM 602272) signaling pathway.
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)Ding, W., et al. Proc. Natl. Acad. Sci. U.S.A. 105(36):13433-13438(2008)Li, C., et al. Mol. Biol. Cell 18(8):3081-3093(2007)Adamowicz, M., et al. Genes Chromosomes Cancer 45(9):829-838(2006)Li, C., et al. Proc. Natl. Acad. Sci. U.S.A. 101(15):5571-5576(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.