|Other Names||Protein naked cuticle homolog 2, Naked-2, hNkd2, NKD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.|
|Cellular Location||Cell membrane. Cytoplasm. Cytoplasmic vesicle|
|Tissue Location||Expressed in kidney, lung, pancreas and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
In the mouse, Nkd is a Dishevelled (see DVL1; MIM601365)-binding protein that functions as a negative regulator ofthe Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf(see MIM 602272) signaling pathway.
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)Ding, W., et al. Proc. Natl. Acad. Sci. U.S.A. 105(36):13433-13438(2008)Li, C., et al. Mol. Biol. Cell 18(8):3081-3093(2007)Adamowicz, M., et al. Genes Chromosomes Cancer 45(9):829-838(2006)Li, C., et al. Proc. Natl. Acad. Sci. U.S.A. 101(15):5571-5576(2004)
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