|Other Names||Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105 kDa subunit, TAF(II)105, TAFII-105, TAFII105, TAF4B, TAF2C2, TAFII105|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.|
|Cellular Location||Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation|
|Tissue Location||Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells|
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Provided below are standard protocols that you may find useful for product applications.
TATA-binding protein associated factors (TAFs)participate, with TATA binding protein (TBP; MIM 600075), in theformation of the TFIID protein complex (see MIM 313650), which isinvolved in the initiation of gene transcription by RNA polymeraseII (see MIM 180660).
Kalogeropoulou, M., et al. Mol. Cancer Res. 8(4):554-568(2010)Gazit, K., et al. J. Biol. Chem. 284(39):26286-26296(2009)Knauff, E.A., et al. Hum. Reprod. 24(9):2372-2378(2009)Teye, K., et al. Int. J. Oncol. 33(6):1271-1280(2008)Liu, W.L., et al. Mol. Cell 29(1):81-91(2008)
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