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PAK6 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NQU5
Clone Names 101008208
Peptide ID 101008208
Additional Information
Gene ID 56924
Other Names Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6, PAK6, PAK5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAK6
Synonyms PAK5
Function Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Cellular Location Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction
Tissue Location Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
Research Areas
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This gene encodes a member of the p21-activated kinase(PAK) family. The proteins of this family are Rac/Cdc42-associatedSte20-like Ser/Thr protein kinases, characterized by a highlyconserved amino-terminal Cdc42/Rac interactive binding (CRIB)domain and a carboxyl-terminal kinase domain. PAK kinases areimplicated in the regulation of a number of cellular processes,including cytoskeleton rearrangement, apoptosis and the MAP kinasesignaling pathway. The protein encoded by this gene was found tointeract with androgen receptor (AR), which is a steroidhormone-dependent transcription factor that is important for malesexual differentiation and development. This gene was found to behighly expressed in testis and prostate tissues and the encodedprotein was shown to cotranslocate into the nucleus with AR inresponse to androgen. Alternatively spliced transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].


Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Lee, E.J., et al. Oncol. Res. 18(9):401-408(2010)Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Shen, M., et al. Environ. Mol. Mutagen. 50(4):285-290(2009)

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$ 80.00
Cat# BP12164c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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