|Other Names||Ras-related and estrogen-regulated growth inhibitor, RERG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.|
|Tissue Location||Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor- positive breast-derived cell lines, but not in estrogen receptor- negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.|
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Provided below are standard protocols that you may find useful for product applications.
RERG, a member of the RAS superfamily of GTPases, inhibitscell proliferation and tumor formation (Finlin et al., 2001 [PubMed11533059]).
Lamesch, P., et al. Genomics 89(3):307-315(2007)Finlin, B.S., et al. J. Biol. Chem. 276(45):42259-42267(2001)
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