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STUB1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UNE7
Clone Names 101109024
Peptide ID 101109024
Additional Information
Gene ID 10273
Other Names E3 ubiquitin-protein ligase CHIP, 632-, Antigen NY-CO-7, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1 {ECO:0000312|HGNC:HGNC:11427}, STUB1 (HGNC:11427)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STUB1 (HGNC:11427)
Function E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg)
Tissue Location Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung
Research Areas
Citations (0)

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STUB1, or CHIP, is a ubiquitin ligase/cochaperone thatparticipates in protein quality control by targeting a broad rangeof chaperone protein substrates for degradation (Min et al., 2008[PubMed 18411298]).


Stankiewicz, M., et al. FEBS J. 277(16):3353-3367(2010)Naito, A.T., et al. Circ. Res. 106(11):1692-1702(2010)Loffek, S., et al. Hum. Mutat. 31(4):466-476(2010)Graf, C., et al. Biochemistry 49(10):2121-2129(2010)Schulke, J.P., et al. PLoS ONE 5 (7), E11717 (2010) :

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$ 80.00
Cat# BP12177b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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