|Other Names||Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, FREAC-6, Hepatocyte nuclear factor 3 forkhead homolog 3, HFH-3, HNF-3/fork-head homolog 3, FOXI1, FKHL10, FREAC6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).|
|Tissue Location||Expressed in kidney.|
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This gene belongs to the forkhead family of transcriptionfactors which is characterized by a distinct forkhead domain. Thespecific function of this gene has not yet been determined;however, it is possible that this gene plays an important role inthe development of the cochlea and vestibulum, as well asembryogenesis. Mutations in this gene may be associated with thecommon cavity phenotype. Two transcript variants encoding differentisoforms have been found for this gene.
Jonard, L., et al. Int. J. Pediatr. Otorhinolaryngol. 74(9):1049-1053(2010)Moreno-Estrada, A., et al. BMC Evol. Biol. 10, 267 (2010) :Vidarsson, H., et al. PLoS ONE 4 (2), E4471 (2009) :Ferrell, R.E., et al. Lymphat Res Biol 6(2):69-76(2008)Rodriguez-Antona, C., et al. Mol. Pharmacol. 63(5):1180-1189(2003)
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