|Other Names||Growth/differentiation factor 9, GDF-9, GDF9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.|
|Tissue Location||Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Growth factors synthesized by ovarian somatic cellsdirectly affect oocyte growth and function. Growth differentiationfactor-9 (GDF9) is expressed in oocytes and is thought to berequired for ovarian folliculogenesis. GDF9 is a member of thetransforming growth factor-beta superfamily.
Bokobza, S.M., et al. J. Cell. Physiol. 225(2):529-536(2010)Wang, T.T., et al. Fertil. Steril. 94(6):2490-2492(2010)Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :Sproul, K., et al. BJOG 117(6):756-760(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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