GDF9 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O60383 |
---|---|
Clone Names | 101109045 |
Gene ID | 2661 |
---|---|
Other Names | Growth/differentiation factor 9, GDF-9, GDF9 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GDF9 |
---|---|
Function | Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. |
Cellular Location | Secreted. |
Tissue Location | Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Growth factors synthesized by ovarian somatic cellsdirectly affect oocyte growth and function. Growth differentiationfactor-9 (GDF9) is expressed in oocytes and is thought to berequired for ovarian folliculogenesis. GDF9 is a member of thetransforming growth factor-beta superfamily.
References
Bokobza, S.M., et al. J. Cell. Physiol. 225(2):529-536(2010)Wang, T.T., et al. Fertil. Steril. 94(6):2490-2492(2010)Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :Sproul, K., et al. BJOG 117(6):756-760(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.