|Other Names||Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGFA, VEGF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).|
|Cellular Location||Secreted Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin|
|Tissue Location||Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland|
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This gene is a member of the PDGF/VEGF growth factorfamily and encodes a protein that is often found as a disulfidelinked homodimer. This protein is a glycosylated mitogen thatspecifically acts on endothelial cells and has various effects,including mediating increased vascular permeability, inducingangiogenesis, vasculogenesis and endothelial cell growth, promotingcell migration, and inhibiting apoptosis. Elevated levels of thisprotein is linked to POEMS syndrome, also known as Crow-Fukasesyndrome. Mutations in this gene have been associated withproliferative and nonproliferative diabetic retinopathy.Alternatively spliced transcript variants, encoding either freelysecreted or cell-associated isoforms, have been characterized.There is also evidence for the use of non-AUG (CUG) translationinitiation sites upstream of, and in-frame with the first AUG,leading to additional isoforms.
Shrivastava-Ranjan, P., et al. J. Virol. 84(21):11227-11234(2010)Kim, Y.H., et al. Gynecol. Oncol. 119(2):232-236(2010)Yang, Y., et al. Exp. Biol. Med. (Maywood) 235(10):1204-1211(2010)Huez, I., et al. Mol. Endocrinol. 15(12):2197-2210(2001)Tee, M.K., et al. Biochem. J. 359 (PT 1), 219-226 (2001) :
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