|Other Names||Poly [ADP-ribose] polymerase 9, PARP-9, ADP-ribosyltransferase diphtheria toxin-like 9, ARTD9, B aggressive lymphoma protein homolog, Parp9, Bal|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol Export to the cytosol depends on the interaction with DTX3L (By similarity). Localizes at sites of DNA damage in a PARP1-dependent manner (By similarity).|
|Tissue Location||Highly expressed in the thymus and intestine.|
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PARP9 is a novel risk related gene that is expressed at higher levels in fatal high risk diffuse large B cell lymphomas.
Hakme, A., et al. Dev. Dyn. 237(1):209-215(2008)
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