|Other Names||Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GCN5, GCN5L2, HGCN5|
|Function||Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.|
|Tissue Location||Expressed in all tissues tested, with most abundant expression in ovary|
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KAT2A, or GCN5, is a histone acetyltransferase (HAT) thatfunctions primarily as a transcriptional activator. It alsofunctions as a repressor of NF-kappa-B (see MIM 164011) bypromoting ubiquitination of the NF-kappa-B subunit RELA (MIM164014) in a HAT-independent manner (Mao et al., 2009 [PubMed19339690]).
Terreni, M., et al. Retrovirology 7, 18 (2010) :Atanassov, B.S., et al. Mol. Cell 35(3):352-364(2009)Kelly, T.J., et al. J. Biol. Chem. 284(30):19945-19952(2009)Mao, X., et al. Genes Dev. 23(7):849-861(2009)Paolinelli, R., et al. Nat. Struct. Mol. Biol. 16(4):412-420(2009)
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