|Other Names||Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GCN5, GCN5L2, HGCN5|
|Function||Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.|
|Tissue Location||Expressed in all tissues tested, with most abundant expression in ovary|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) thatfunctions primarily as a transcriptional activator. It alsofunctions as a repressor of NF-kappa-B (see MIM 164011) bypromoting ubiquitination of the NF-kappa-B subunit RELA (MIM164014) in a HAT-independent manner (Mao et al., 2009 [PubMed19339690]).
Terreni, M., et al. Retrovirology 7, 18 (2010) :Atanassov, B.S., et al. Mol. Cell 35(3):352-364(2009)Kelly, T.J., et al. J. Biol. Chem. 284(30):19945-19952(2009)Mao, X., et al. Genes Dev. 23(7):849-861(2009)Paolinelli, R., et al. Nat. Struct. Mol. Biol. 16(4):412-420(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.