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p130cas Antibody (Center Y224) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P56945 |
|---|---|
| Clone Names | 80722071 |
| Gene ID | 9564 |
|---|---|
| Other Names | Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BCAR1 |
|---|---|
| Synonyms | CAS, CASS1, CRKAS |
| Function | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12832404, PubMed:12432078). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). |
| Cellular Location | Cell junction, focal adhesion. Cytoplasm Cell projection, axon {ECO:0000250|UniProtKB:Q61140} Note=Unphosphorylated form localizes in the cytoplasm (By similarity) Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140} |
| Tissue Location | Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512) |
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Provided below are standard protocols that you may find useful for product applications.
Background
BCAR1, or CAS, is an Src (MIM 190090) family kinasesubstrate involved in various cellular events, including migration,survival, transformation, and invasion (Sawada et al., 2006 [PubMed17129785]).
References
Tai, C.J., et al. Exp. Cell Res. 316(17):2969-2981(2010)Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Schuh, N.R., et al. J. Biol. Chem. 285(4):2309-2317(2010)Wendt, M.K., et al. J. Biol. Chem. 284(49):34145-34156(2009)Qian, X., et al. Cancer Cell 16(3):246-258(2009)
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