|Other Names||Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAS, CASS1, CRKAS|
|Function||Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.|
|Cellular Location||Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.|
|Tissue Location||Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line|
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BCAR1, or CAS, is an Src (MIM 190090) family kinasesubstrate involved in various cellular events, including migration,survival, transformation, and invasion (Sawada et al., 2006 [PubMed17129785]).
Tai, C.J., et al. Exp. Cell Res. 316(17):2969-2981(2010)Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Schuh, N.R., et al. J. Biol. Chem. 285(4):2309-2317(2010)Wendt, M.K., et al. J. Biol. Chem. 284(49):34145-34156(2009)Qian, X., et al. Cancer Cell 16(3):246-258(2009)
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