|Other Names||Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, EPHX1, EPHX, EPOX|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|
|Cellular Location||Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Found in liver..|
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Epoxide hydrolase is a critical biotransformation enzymethat converts epoxides from the degradation of aromatic compoundsto trans-dihydrodiols which can be conjugated and excreted from thebody. Epoxide hydrolase functions in both the activation anddetoxification of epoxides. Mutations in this gene causepreeclampsia, epoxide hydrolase deficiency or increased epoxidehydrolase activity. Alternatively spliced transcript variantsencoding the same protein have been found for this gene.
Pande, M., et al. Mol. Carcinog. 49(11):974-980(2010)Schelleman, H., et al. Br J Clin Pharmacol 70(3):393-399(2010)Chauhan, P.S., et al. DNA Cell Biol. (2010) In press :Ihsan, R., et al. J. Gastroenterol. Hepatol. 25(8):1456-1462(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
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