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EPHX1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07099 |
|---|---|
| Clone Names | 100311147 |
| Gene ID | 2052 |
|---|---|
| Other Names | Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, EPHX1, EPHX, EPOX |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EPHX1 (HGNC:3401) |
|---|---|
| Synonyms | EPHX, EPOX |
| Function | Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). |
| Cellular Location | Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P07687}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P07687} |
| Tissue Location | Found in liver.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Epoxide hydrolase is a critical biotransformation enzymethat converts epoxides from the degradation of aromatic compoundsto trans-dihydrodiols which can be conjugated and excreted from thebody. Epoxide hydrolase functions in both the activation anddetoxification of epoxides. Mutations in this gene causepreeclampsia, epoxide hydrolase deficiency or increased epoxidehydrolase activity. Alternatively spliced transcript variantsencoding the same protein have been found for this gene.
References
Pande, M., et al. Mol. Carcinog. 49(11):974-980(2010)Schelleman, H., et al. Br J Clin Pharmacol 70(3):393-399(2010)Chauhan, P.S., et al. DNA Cell Biol. (2010) In press :Ihsan, R., et al. J. Gastroenterol. Hepatol. 25(8):1456-1462(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
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