|Other Names||Histone H31t, H3/t, H3t, H3/g, HIST3H3, H3FT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
|Tissue Location||Expressed in testicular cells.|
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Provided below are standard protocols that you may find useful for product applications.
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H3 family. Transcripts from this gene lack polyA tails;instead, they contain a palindromic termination element. This geneis located separately from the other H3 genes that are in thehistone gene cluster on chromosome 6p22-p21.3. [provided byRefSeq].
Tachiwana, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10454-10459(2010)Nair, S.S., et al. EMBO Rep. 11(6):438-444(2010)Rampakakis, E., et al. J. Cell. Biochem. 108(2):400-407(2009)Mochizuki, K., et al. Biochem. Biophys. Res. Commun. 371(2):324-327(2008)Meyer, K.D., et al. EMBO J. 27(10):1447-1457(2008)
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