|Other Names||Tubulin alpha-1A chain, Alpha-tubulin 3, Tubulin B-alpha-1, Tubulin alpha-3 chain, TUBA1A, TUBA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Expressed at a high level in fetal brain.|
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Microtubules of the eukaryotic cytoskeleton performessential and diverse functions and are composed of a heterodimerof alpha and beta tubulins. The genes encoding these microtubuleconstituents belong to the tubulin superfamily, which is composedof six distinct families. Genes from the alpha, beta and gammatubulin families are found in all eukaryotes. The alpha and betatubulins represent the major components of microtubules, whilegamma tubulin plays a critical role in the nucleation ofmicrotubule assembly. There are multiple alpha and beta tubulingenes, which are highly conserved among species. This gene encodesalpha tubulin and is highly similar to mouse and rat Tuba1 gene.Northern blotting studies have shown that the gene expression ispredominantly found in morphologically differentiated neurologiccells. This gene is one of three alpha-tubulin genes in a clusteron chromosome 12q.
Kumar, R.A., et al. Hum. Mol. Genet. 19(14):2817-2827(2010)Tomppo, L., et al. Biol. Psychiatry 65(12):1055-1062(2009)Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :Morris-Rosendahl, D.J., et al. Clin. Genet. 74(5):425-433(2008)Bahi-Buisson, N., et al. J. Med. Genet. 45(10):647-653(2008)
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