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TUBA1A Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q71U36 |
|---|---|
| Clone Names | 100311181 |
| Gene ID | 7846 |
|---|---|
| Other Names | Tubulin alpha-1A chain, Alpha-tubulin 3, Tubulin B-alpha-1, Tubulin alpha-3 chain, TUBA1A, TUBA3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TUBA1A |
|---|---|
| Synonyms | TUBA3 |
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Cellular Location | Cytoplasm, cytoskeleton. |
| Tissue Location | Expressed at a high level in fetal brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Microtubules of the eukaryotic cytoskeleton performessential and diverse functions and are composed of a heterodimerof alpha and beta tubulins. The genes encoding these microtubuleconstituents belong to the tubulin superfamily, which is composedof six distinct families. Genes from the alpha, beta and gammatubulin families are found in all eukaryotes. The alpha and betatubulins represent the major components of microtubules, whilegamma tubulin plays a critical role in the nucleation ofmicrotubule assembly. There are multiple alpha and beta tubulingenes, which are highly conserved among species. This gene encodesalpha tubulin and is highly similar to mouse and rat Tuba1 gene.Northern blotting studies have shown that the gene expression ispredominantly found in morphologically differentiated neurologiccells. This gene is one of three alpha-tubulin genes in a clusteron chromosome 12q.
References
Kumar, R.A., et al. Hum. Mol. Genet. 19(14):2817-2827(2010)Tomppo, L., et al. Biol. Psychiatry 65(12):1055-1062(2009)Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :Morris-Rosendahl, D.J., et al. Clin. Genet. 74(5):425-433(2008)Bahi-Buisson, N., et al. J. Med. Genet. 45(10):647-653(2008)
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