|Other Names||Rho GTPase-activating protein 8, Rho-type GTPase-activating protein 8, ARHGAP8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.|
|Tissue Location||Highly expressed in kidney and placenta. Also expressed in colon, skeletal muscle, small intestine, stomach, and testis. Not detected in brain, liver or spleen. Overexpressed in the majority of colorectal tumors examined|
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This gene encodes a member of the RHOGAP family. GAP(GTPase-activating) family proteins participate in signalingpathways that regulate cell processes involved in cytoskeletalchanges. GAP proteins alternate between an active (GTP-bound) andinactive (GDP-bound) state based on the GTP:GDP ratio in the cell.This family member is a multidomain protein that functions topromote Erk activation and cell motility. Alternative splicingresults in multiple transcript variants. Read-through transcriptsfrom the upstream proline rich 5, renal (PRR5) gene into this genealso exist, which led to the original description of PRR5 andARHGAP8 being a single gene.
Pan, C.Q., et al. J. Cell. Sci. 123 (PT 6), 903-916 (2010) :Song, J.Y., et al. Int. J. Gynecol. Cancer 18(5):1051-1059(2008)Komor, M., et al. Stem Cells 23(8):1154-1169(2005)Lua, B.L., et al. J. Cell. Sci. 118 (PT 12), 2707-2721 (2005) :Lua, B.L., et al. Biochem. Soc. Trans. 32 (PT 6), 1110-1112 (2004) :
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