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RTN4R Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BZR6
Clone Names 101008268
Peptide ID 101008268
Additional Information
Gene ID 65078
Other Names Reticulon-4 receptor, Nogo receptor, NgR, Nogo-66 receptor, RTN4R, NOGOR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN4R
Synonyms NOGOR
Function Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).
Cellular Location Cell membrane; Lipid- anchor, GPI-anchor. Membrane raft. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses {ECO:0000250|UniProtKB:Q99PI8}
Tissue Location Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney; not expressed in oligodendrocytes (white matter).
Research Areas
Citations (0)

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Background

This gene encodes the receptor for reticulon 4,oligodendrocyte myelin glycoprotein and myelin-associatedglycoprotein. This receptor mediates axonal growth inhibition andmay play a role in regulating axonal regeneration and plasticity inthe adult central nervous system.

References

Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Raiker, S.J., et al. J. Neurosci. 30(37):12432-12445(2010)Lee, E.J., et al. Oncol. Res. 18(9):401-408(2010)Zhang, L., et al. J. Neurosci. 29(19):6348-6352(2009)Voineskos, A.N. J. Neurosci. 29(16):5045-5047(2009)

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$ 80.00
Cat# BP12238c
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