|Other Names||Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.|
|Cellular Location||Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transcription factor that wasoriginally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in theLTR of HTLV-1. The encoded protein was also isolated andcharacterized as the cAMP-response element binding protein 2(CREB-2). The protein encoded by this gene belongs to a family ofDNA-binding proteins that includes the AP-1 family of transcriptionfactors, cAMP-response element binding proteins (CREBs) andCREB-like proteins. These transcription factors share a leucinezipper region that is involved in protein-protein interactions,located C-terminal to a stretch of basic amino acids that functionsas a DNA binding domain. Two alternative transcripts encoding thesame protein have been described. Two pseudogenes are located onthe X chromsome at q28 in a region containing a large invertedduplication.
Dey, S., et al. J. Biol. Chem. 285(43):33165-33174(2010)Frank, C.L., et al. J. Biol. Chem. 285(43):33324-33337(2010)Rzymski, T., et al. Oncogene 29(31):4424-4435(2010)Liew, C.W., et al. J. Clin. Invest. 120(8):2876-2888(2010)Wek, R.C., et al. EMBO J. 29(12):1946-1947(2010)
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