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ATF4 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P18848
Clone Names 101109031
Peptide ID 101109031
Additional Information
Gene ID 468
Other Names Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATF4
Synonyms CREB2, TXREB
Function Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
Cellular Location Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome.
Research Areas
Citations (0)

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This gene encodes a transcription factor that wasoriginally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in theLTR of HTLV-1. The encoded protein was also isolated andcharacterized as the cAMP-response element binding protein 2(CREB-2). The protein encoded by this gene belongs to a family ofDNA-binding proteins that includes the AP-1 family of transcriptionfactors, cAMP-response element binding proteins (CREBs) andCREB-like proteins. These transcription factors share a leucinezipper region that is involved in protein-protein interactions,located C-terminal to a stretch of basic amino acids that functionsas a DNA binding domain. Two alternative transcripts encoding thesame protein have been described. Two pseudogenes are located onthe X chromsome at q28 in a region containing a large invertedduplication.


Dey, S., et al. J. Biol. Chem. 285(43):33165-33174(2010)Frank, C.L., et al. J. Biol. Chem. 285(43):33324-33337(2010)Rzymski, T., et al. Oncogene 29(31):4424-4435(2010)Liew, C.W., et al. J. Clin. Invest. 120(8):2876-2888(2010)Wek, R.C., et al. EMBO J. 29(12):1946-1947(2010)

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$ 80.00
Cat# BP12242c
(40 western blots)
Availability: In Stock
Bulk Size
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