|Other Names||Sorting nexin-13, RGS domain- and PHOX domain-containing protein, RGS-PX1, SNX13, KIAA0713|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein; Cytoplasmic side|
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This gene encodes a PHOX domain- and RGS domain-containingprotein that belongs to the sorting nexin (SNX) family and theregulator of G protein signaling (RGS) family. The PHOX domain is aphosphoinositide binding domain, and the SNX family members areinvolved in intracellular trafficking. The RGS family members areregulatory molecules that act as GTPase activating proteins for Galpha subunits of heterotrimeric G proteins. The RGS domain of thisprotein interacts with G alpha(s), accelerates its GTP hydrolysis,and attenuates G alpha(s)-mediated signaling. Overexpression ofthis protein delayes lysosomal degradation of the epidermal growthfactor receptor. Because of its bifunctional role, this protein maylink heterotrimeric G protein signaling and vesicular trafficking.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :Worby, C.A., et al. Nat. Rev. Mol. Cell Biol. 3(12):919-931(2002)Kosan, C., et al. Cytogenet. Genome Res. 97 (3-4), 167-170 (2002) :Zheng, B., et al. Science 294(5548):1939-1942(2001)
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