|Other Names||Aldo-keto reductase family 1 member C2, 1---, 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, AKR1C2, DDH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.|
|Tissue Location||Expressed in fetal testes. Expressed in fetal and adult adrenal glands.|
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This gene encodes a member of the aldo/keto reductasesuperfamily, which consists of more than 40 known enzymes andproteins. These enzymes catalyze the conversion of aldehydes andketones to their corresponding alcohols using NADH and/or NADPH ascofactors. The enzymes display overlapping but distinct substratespecificity. This enzyme binds bile acid with high affinity, andshows minimal 3-alpha-hydroxysteroid dehydrogenase activity. Thisgene shares high sequence identity with three other gene membersand is clustered with those three genes at chromosome 10p15-p14.
Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):229-239(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Reding, K.W., et al. Am. J. Epidemiol. 170(10):1241-1249(2009)Cogliati, C., et al. FEBS J. 276(20):6011-6023(2009)Davies, N.J., et al. Cancer Res. 69(11):4769-4775(2009)
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