|Other Names||Rho GTPase-activating protein 15, ArhGAP15, Rho-type GTPase-activating protein 15, ARHGAP15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Expressed in lung, liver and lymphoid cells.|
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Provided below are standard protocols that you may find useful for product applications.
RHO GTPases (see ARHA; MIM 165390) regulate diversebiologic processes, and their activity is regulated by RHOGTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al.,2003 [PubMed 12650940]).
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :Rose, J. Phd, et al. Mol. Med. (2010) In press :Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Satoh, J., et al. Neuropathol. Appl. Neurobiol. 35(1):16-35(2009)Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
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