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SRC1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15788 |
|---|---|
| Clone Names | 71130153 |
| Gene ID | 8648 |
|---|---|
| Other Names | Nuclear receptor coactivator 1, NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1, NCOA1, BHLHE74, SRC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NCOA1 |
|---|---|
| Synonyms | BHLHE74, SRC1 |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene acts as a transcriptionalcoactivator for steroid and nuclear hormone receptors. It is amember of the p160/steroid receptor coactivator (SRC) family andlike other family members has histone acetyltransferase activityand contains a nuclear localization signal, as well as bHLH and PASdomains. The product of this gene binds nuclear receptors directlyand stimulates the transcriptional activities in ahormone-dependent fashion. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Son, Y.L., et al. FEBS Lett. 584(18):3862-3866(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :McIlroy, M., et al. Cancer Res. 70(4):1585-1594(2010)Hartmaier, R.J., et al. BMC Cancer 9, 438 (2009) :
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