|Other Names||Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neurite outgrowth-promoting factor 1, HBNF-1, Osteoblast-specific factor 1, OSF-1, PTN, HBNF1, NEGF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation.|
|Tissue Location||Osteoblast and brain.|
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Provided below are standard protocols that you may find useful for product applications.
PTN ia a heparin binding mitogenic protein. It has neurite extension activity.
Li, F., et al. J. Biol. Chem. 285(36):27673-27685(2010)Dos Santos, C., et al. Int. J. Cancer 127(5):1038-1051(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Svensson, S.L., et al. J. Biol. Chem. 285(21):16105-16115(2010)M'Bika, J.P., et al. J. Gen. Virol. 91 (PT 5), 1346-1353 (2010) :
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