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TPSAB1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15661
Clone Names 80924257
Peptide ID 80924257
Additional Information
Gene ID 7177
Other Names Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TPS1, TPS2, TPSB1
Function Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Cellular Location Secreted. Note=Released from the secretory granules upon mast cell activation.
Tissue Location Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level)
Research Areas
Citations (0)

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Tryptases comprise a family of trypsin-like serineproteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistantto all known endogenous proteinase inhibitors. Several tryptasegenes are clustered on chromosome 16p13.3. These genes arecharacterized by several distinct features. They have a highlyconserved 3' UTR and contain tandem repeat sequences at the 5'flank and 3' UTR which are thought to play a role in regulation ofthe mRNA stability. These genes have an intron immediately upstreamof the initiator Met codon, which separates the site oftranscription initiation from protein coding sequence. This featureis characteristic of tryptases but is unusual in other genes. Thealleles of this gene exhibit an unusual amount of sequencevariation, such that the alleles were once thought to represent twoseparate genes, alpha and beta 1. Beta tryptases appear to be themain isoenzymes expressed in mast cells; whereas in basophils,alpha tryptases predominate. Tryptases have been implicated asmediators in the pathogenesis of asthma and other allergic andinflammatory disorders.


Lee, J.W., et al. Dig. Dis. Sci. 55(10):2922-2928(2010)Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124(5):1099-1105(2009)Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)Schiemann, F., et al. J. Immunol. 183(4):2223-2231(2009)Wei, Z.Y., et al. Fa Yi Xue Za Zhi 25(3):164-167(2009)

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$ 80.00
Cat# BP12270b
Availability: In Stock
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