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TRAIL Antibody (Center N109) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P50591
Clone Names 81020083
Peptide ID 81020083
Additional Information
Gene ID 8743
Other Names Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF10
Synonyms APO2L, TRAIL
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Cellular Location Membrane; Single-pass type II membrane protein
Tissue Location Widespread; most predominant in spleen, lung and prostate
Research Areas
Citations (0)

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The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thisprotein preferentially induces apoptosis in transformed and tumorcells, but does not appear to kill normal cells although it isexpressed at a significant level in most normal tissues. Thisprotein binds to several members of TNF receptor superfamilyincluding TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activityof this protein may be modulated by binding to the decoy receptorsTNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannotinduce apoptosis. The binding of this protein to its receptors hasbeen shown to trigger the activation of MAPK8/JNK, caspase 8, andcaspase 3. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].


Morales, J.C., et al. Cancer Lett. 297(1):91-100(2010)Wei, W., et al. Mol. Immunol. 47(15):2475-2484(2010)Niu, T.K., et al. FEBS Lett. 584(16):3519-3524(2010)Pal, R., et al. Breast Cancer Res. Treat. (2010) In press :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 80.00
Cat# BP12271c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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