|Other Names||POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1, POU6F2, RPF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.|
|Tissue Location||Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina|
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This gene encodes a member of the POU protein familycharacterized by the presence of a bipartite DNA binding domain,consisting of a POU-specific domain and a homeodomain, separated bya variable polylinker. The DNA binding domain may bind to DNA asmonomers or as homo- and/or heterodimers, in a sequence-specificmanner. The POU family members are transcriptional regulators, manyof which are known to control cell type-specific differentiationpathways. This gene is a tumor suppressor involved in Wilms tumor(WT) predisposition. Alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene.
Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Di Renzo, F., et al. J. Pediatr. Hematol. Oncol. 28(12):791-797(2006)Perotti, D., et al. J. Pediatr. Hematol. Oncol. 27(10):521-525(2005)
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