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POU6F2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P78424
Clone Names 101008213
Peptide ID 101008213
Additional Information
Gene ID 11281
Other Names POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1, POU6F2, RPF1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name POU6F2
Synonyms RPF1
Function Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.
Cellular Location Nucleus.
Tissue Location Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina
Research Areas
Citations (0)

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Background

This gene encodes a member of the POU protein familycharacterized by the presence of a bipartite DNA binding domain,consisting of a POU-specific domain and a homeodomain, separated bya variable polylinker. The DNA binding domain may bind to DNA asmonomers or as homo- and/or heterodimers, in a sequence-specificmanner. The POU family members are transcriptional regulators, manyof which are known to control cell type-specific differentiationpathways. This gene is a tumor suppressor involved in Wilms tumor(WT) predisposition. Alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene.

References

Anney, R., et al. Hum. Mol. Genet. 19(20):4072-4082(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Di Renzo, F., et al. J. Pediatr. Hematol. Oncol. 28(12):791-797(2006)Perotti, D., et al. J. Pediatr. Hematol. Oncol. 27(10):521-525(2005)

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$ 80.00
Cat# BP12281a
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