|Other Names||Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta- glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney Down-regulated in renal cell carcinomas and hepatocellular carcinomas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
GBA3, or cytosolic beta-glucosidase (EC 126.96.36.199), is apredominantly liver enzyme that efficiently hydrolyzesbeta-D-glucoside and beta-D-galactoside, but not any knownphysiologic beta-glycoside, suggesting that it may be involved indetoxification of plant glycosides (de Graaf et al., 2001 [PubMed11389701]). GBA3 also has significant neutral glycosylceramidaseactivity (EC 188.8.131.52), suggesting that it may be involved in anonlysosomal catabolic pathway of glucosylceramide metabolism(Hayashi et al., 2007 [PubMed 17595169]).
Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374(3):549-552(2008)Hayashi, Y., et al. J. Biol. Chem. 282(42):30889-30900(2007)Tribolo, S., et al. J. Mol. Biol. 370(5):964-975(2007)Beutler, E., et al. J. Lab. Clin. Med. 144(2):65-68(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.