|Other Names||Serglycin, Hematopoietic proteoglycan core protein, Platelet proteoglycan core protein, PPG, Secretory granule proteoglycan core protein, SRGN, PRG, PRG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization.|
|Cellular Location||Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation|
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This gene encodes a protein best known as a hematopoieticcell granule proteoglycan. Proteoglycans stored in the secretorygranules of many hematopoietic cells also contain aprotease-resistant peptide core, which may be important forneutralizing hydrolytic enzymes. This encoded protein was found tobe associated with the macromolecular complex of granzymes andperforin, which may serve as a mediator of granule-mediatedapoptosis. Two transcript variants, only one of themprotein-coding, have been found for this gene. [provided byRefSeq].
Ma, D., et al. Pediatr Blood Cancer 50(5):1067-1069(2008)Kolset, S.O., et al. Glycoconj. J. 25(4):305-311(2008)Theocharis, A.D., et al. J. Biol. Chem. 281(46):35116-35128(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Raja, S.M., et al. J. Biol. Chem. 280(21):20752-20761(2005)
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