|Other Names||Solute carrier family 22 member 3, Extraneuronal monoamine transporter, EMT, Organic cation transporter 3, SLC22A3, EMTH, OCT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen|
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Polyspecific organic cation transporters in the liver,kidney, intestine, and other organs are critical for elimination ofmany endogenous small organic cations as well as a wide array ofdrugs and environmental toxins. This gene is one of three similarcation transporter genes located in a cluster on chromosome 6. Theencoded protein contains twelve putative transmembrane domains andis a plasma integral membrane protein.
Bao, B.Y., et al. Clin. Chim. Acta 411 (17-18), 1232-1237 (2010) :Liu, H., et al. Prostate (2010) In press :Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)Sallinen, R., et al. Ann. Med. 42(4):296-304(2010)Sakata, T., et al. J. Pharmacol. Sci. 113(3):263-266(2010)
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