|Other Names||Solute carrier family 22 member 3, Extraneuronal monoamine transporter, EMT, Organic cation transporter 3, SLC22A3, EMTH, OCT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen|
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Provided below are standard protocols that you may find useful for product applications.
Polyspecific organic cation transporters in the liver,kidney, intestine, and other organs are critical for elimination ofmany endogenous small organic cations as well as a wide array ofdrugs and environmental toxins. This gene is one of three similarcation transporter genes located in a cluster on chromosome 6. Theencoded protein contains twelve putative transmembrane domains andis a plasma integral membrane protein.
Bao, B.Y., et al. Clin. Chim. Acta 411 (17-18), 1232-1237 (2010) :Liu, H., et al. Prostate (2010) In press :Gallagher, D.J., et al. Clin. Cancer Res. 16(10):2819-2832(2010)Sallinen, R., et al. Ann. Med. 42(4):296-304(2010)Sakata, T., et al. J. Pharmacol. Sci. 113(3):263-266(2010)
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