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PDE6B Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P35913
Clone Names 100318017
Additional Information
Gene ID 5158
Other Names Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, PDE6B, PDEB
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE6B (HGNC:8786)
Synonyms PDEB
Function Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174).
Cellular Location Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment
Research Areas
Citations (0)
citation

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Background

Photon absorption triggers a signaling cascade in rodphotoreceptors that activates cGMP phosphodiesterase (PDE),resulting in the rapid hydrolysis of cGMP, closure of cGMP-gatedcation channels, and hyperpolarization of the cell. PDE is aperipheral membrane heterotrimeric enzyme made up of alpha, beta,and gamma subunits. This gene encodes the beta subunit. Mutationsin this gene result in retinitis pigmentosa and autosomal dominantcongenital stationary night blindness. Multiple transcript variantsencoding different isoforms have been found for this gene.

References

Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Verardo, M.R., et al. Invest. Ophthalmol. Vis. Sci. 50(6):2591-2598(2009)Hmani-Aifa, M., et al. Eur. J. Hum. Genet. 17(4):474-482(2009)Sui, R., et al. Adv. Exp. Med. Biol. 613, 245-252 (2008) :

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$ 277.78
Cat# BP12294b
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