|Other Names||Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, PDE6B, PDEB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.|
|Cellular Location||Membrane; Lipid-anchor.|
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Provided below are standard protocols that you may find useful for product applications.
Photon absorption triggers a signaling cascade in rodphotoreceptors that activates cGMP phosphodiesterase (PDE),resulting in the rapid hydrolysis of cGMP, closure of cGMP-gatedcation channels, and hyperpolarization of the cell. PDE is aperipheral membrane heterotrimeric enzyme made up of alpha, beta,and gamma subunits. This gene encodes the beta subunit. Mutationsin this gene result in retinitis pigmentosa and autosomal dominantcongenital stationary night blindness. Multiple transcript variantsencoding different isoforms have been found for this gene.
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Verardo, M.R., et al. Invest. Ophthalmol. Vis. Sci. 50(6):2591-2598(2009)Hmani-Aifa, M., et al. Eur. J. Hum. Genet. 17(4):474-482(2009)Sui, R., et al. Adv. Exp. Med. Biol. 613, 245-252 (2008) :
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