PDE6B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P35913 |
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Clone Names | 100318017 |
Gene ID | 5158 |
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Other Names | Rod cGMP-specific 3', 5'-cyclic phosphodiesterase subunit beta, GMP-PDE beta, PDE6B, PDEB |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PDE6B (HGNC:8786) |
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Synonyms | PDEB |
Function | Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). Necessary for the formation of a functional phosphodiesterase holoenzyme (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity). May participate in processes of transmission and amplification of the visual signal (PubMed:8394174). |
Cellular Location | Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment |
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Provided below are standard protocols that you may find useful for product applications.
Background
Photon absorption triggers a signaling cascade in rodphotoreceptors that activates cGMP phosphodiesterase (PDE),resulting in the rapid hydrolysis of cGMP, closure of cGMP-gatedcation channels, and hyperpolarization of the cell. PDE is aperipheral membrane heterotrimeric enzyme made up of alpha, beta,and gamma subunits. This gene encodes the beta subunit. Mutationsin this gene result in retinitis pigmentosa and autosomal dominantcongenital stationary night blindness. Multiple transcript variantsencoding different isoforms have been found for this gene.
References
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Verardo, M.R., et al. Invest. Ophthalmol. Vis. Sci. 50(6):2591-2598(2009)Hmani-Aifa, M., et al. Eur. J. Hum. Genet. 17(4):474-482(2009)Sui, R., et al. Adv. Exp. Med. Biol. 613, 245-252 (2008) :
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