|Other Names||Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K(+) channel Kir23, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization|
|Tissue Location||Heart, skeletal muscle, and several different brain regions including the hippocampus|
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Several different potassium channels are known to beinvolved with electrical signaling in the nervous system. One classis activated by depolarization whereas a second class is not. Thelatter are referred to as inwardly rectifying K+ channels, and theyhave a greater tendency to allow potassium to flow into the cellrather than out of it. This asymmetry in potassium ion conductanceplays a key role in the excitability of muscle cells and neurons.The protein encoded by this gene is an integral membrane proteinand member of the inward rectifier potassium channel family. Theencoded protein has a small unitary conductance compared to othermembers of this protein family. Two transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Yan, X., et al. J. Mol. Biol. 392(4):967-976(2009)He, Y., et al. FEBS Lett. 582(15):2338-2342(2008)Ji, W., et al. Nat. Genet. 40(5):592-599(2008)Ureche, O.N., et al. Cell. Physiol. Biochem. 21 (5-6), 347-356 (2008) :
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