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FYB Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O15117
Clone Names 100318057
Peptide ID 100318057
Additional Information
Gene ID 2533
Other Names FYN-binding protein, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein, FYB, SLAP130
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FYB
Synonyms SLAP130
Function Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.
Cellular Location Cytoplasm. Nucleus. Cell junction {ECO:0000250|UniProtKB:O35601}
Tissue Location Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues
Research Areas
Citations (0)

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Background

FYB acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Srivastava, R., et al. J. Biol. Chem. 285(15):11100-11105(2010)Lehmann, R., et al. Proteomics 9(23):5288-5295(2009)Voss, M., et al. BMC Immunol. 10, 53 (2009) :Burbach, B.J., et al. J. Immunol. 181(7):4840-4851(2008)

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$ 80.00
Cat# BP12307b
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