|Other Names||Calumenin, Crocalbin, IEF SSP 9302, CALU|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).|
|Cellular Location||Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene is a calcium-binding proteinlocalized in the endoplasmic reticulum (ER) and it is involved insuch ER functions as protein folding and sorting. This proteinbelongs to a family of multiple EF-hand proteins (CERC) thatinclude reticulocalbin, ERC-55, and Cab45 and the product of thisgene. Alternatively spliced transcript variants encoding differentisoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Carlquist, J.F., et al. J. Thromb. Thrombolysis 30(3):358-364(2010)Hernandez-Romero, D., et al. Ann. Med. 42(6):439-446(2010)Harada, T., et al. Thromb. Res. 126(3):183-190(2010)Voora, D., et al. Clin. Pharmacol. Ther. 87(4):445-451(2010)
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