|Other Names||Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||B7DC, CD273, PDCD1L2, PDL2|
|Function||Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).|
|Cellular Location||Isoform 3: Secreted. Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
Ellis, J.S., et al. J. Immunol. 185(6):3149-3157(2010)Pena-Cruz, V., et al. J. Invest. Dermatol. 130(9):2222-2230(2010)Ghiotto, M., et al. Int. Immunol. 22(8):651-660(2010)Ishizaki, Y., et al. Hum. Genet. (2010) In press :Kassel, R., et al. Hepatology 50(5):1625-1637(2009)
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