PDCD1LG2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BQ51 |
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Clone Names | 100318076 |
Gene ID | 80380 |
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Other Names | Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PDCD1LG2 |
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Synonyms | B7DC, CD273, PDCD1L2, PDL2 |
Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). |
Cellular Location | [Isoform 3]: Secreted [Isoform 1]: Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9WUL5, ECO:0000305|PubMed:15340161} |
Tissue Location | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
References
Ellis, J.S., et al. J. Immunol. 185(6):3149-3157(2010)Pena-Cruz, V., et al. J. Invest. Dermatol. 130(9):2222-2230(2010)Ghiotto, M., et al. Int. Immunol. 22(8):651-660(2010)Ishizaki, Y., et al. Hum. Genet. (2010) In press :Kassel, R., et al. Hepatology 50(5):1625-1637(2009)
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