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HAX1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00165 |
|---|---|
| Clone Names | 100318085 |
| Gene ID | 10456 |
|---|---|
| Other Names | HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1, HAX1, HS1BP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HAX1 |
|---|---|
| Synonyms | HS1BP1 |
| Function | Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex (PubMed:26997484). Slows down the rate of inactivation of KCNC3 channels (PubMed:26997484). Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. |
| Cellular Location | Mitochondrion matrix. Endoplasmic reticulum Nucleus membrane. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O35387}. Cytoplasm, cell cortex. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q7TSE9}. Cytoplasm, P-body [Isoform 3]: Cytoplasm. Nucleus Note=Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro). [Isoform 5]: Cytoplasm. Note=Predominantly cytoplasmic |
| Tissue Location | Ubiquitous. Up-regulated in oral cancers. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is known to associatewith hematopoietic cell-specific Lyn substrate 1, a substrate ofSrc family tyrosine kinases. It also interacts with the product ofthe polycystic kidney disease 2 gene, mutations in which areassociated with autosomal-dominant polycystic kidney disease, andwith the F-actin-binding protein, cortactin. It was earlier thoughtthat this gene product is mainly localized in the mitochondria,however, recent studies indicate it to be localized in the cellbody. Mutations in this gene result in autosomal recessive severecongenital neutropenia, also known as Kostmann disease. Twotranscript variants encoding different isoforms have been found forthis gene.
References
Johns, H.L., et al. J. Gen. Virol. 91 (PT 11), 2677-2686 (2010) :Mekkawy, A.H., et al. Biochem. Biophys. Res. Commun. 399(4):738-743(2010)Han, J., et al. J. Biol. Chem. 285(29):22461-22472(2010)Germeshausen, M., et al. Haematologica 95(7):1207-1210(2010)Burnicka-Turek, O., et al. BMC Cell Biol. 11, 28 (2010) :
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