|Other Names||Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, SLC12A1, NKCC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Kidney specific.|
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This gene encodes a kidney-specificsodium-potassium-chloride cotransporter that is expressed on theluminal membrane of renal epithelial cells of the thick ascendinglimb of Henle's loop and the macula densa. It plays a key role inconcentrating urine and accounts for most of the NaCl resorption.It is sensitive to such diuretics as furosemide and bumetanide.Some Bartter-like syndromes result from defects in this gene.Alternative splicing results in multiple transcript variantsencoding distinct isoforms. Additional splice variants have beendescribed but their biological validity in humans has not beenexperimentally proven.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Carota, I., et al. Acta Physiol (Oxf) 199(3):327-338(2010)Bralten, L.B., et al. Genes Chromosomes Cancer 49(6):509-517(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Castrop, H., et al. Am. J. Physiol. Renal Physiol. 295 (4), F859-F866 (2008) :
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