|Other Names||Lymphoid-specific helicase, 364-, Proliferation-associated SNF2-like protein, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, HELLS (HGNC:4861)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).|
|Cellular Location||Nucleus. Note=Closely associated with pericentric heterochromatin.|
|Tissue Location||Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias|
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This gene encodes a lymphoid-specific helicase. Otherhelicases function in processes involving DNA strand separation,including replication, repair, recombination, and transcription.This protein is thought to be involved with cellular proliferationand may play a role in leukemogenesis. Alternatively splicedtranscript variants have been described, but their biologicalvalidity has not been determined.
Zhou, R., et al. Nucleic Acids Res. 37(15):5183-5196(2009)Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3567-3572(2008)Suzuki, T., et al. Epigenetics 3(5):281-291(2008)Myant, K., et al. Mol. Cell. Biol. 28(1):215-226(2008)Yano, M., et al. Int. J. Cancer 112(1):8-13(2004)
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