|Other Names||Nuclear protein MDM1, MDM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the centriole lumen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein similar to the mousedouble minute 1 protein. The mouse gene is located in double minute(DM) chromatin particles and is amplified in the mouse transformed3T3 cell line, and the protein is able to bind to p53. In mouseseveral transcripts have been described for this gene which resultfrom alternative polyadenylation, splicing and exon usage.
Chang, B., et al. Hum. Mol. Genet. 17(24):3929-3941(2008)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Snyder, L.C., et al. J. Biol. Chem. 263(32):17150-17158(1988)
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