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MAD1L1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y6D9 |
|---|---|
| Clone Names | 81202095 |
| Gene ID | 8379 |
|---|---|
| Other Names | Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181, MAD1L1, MAD1, TXBP181 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAD1L1 |
|---|---|
| Synonyms | MAD1, TXBP181 |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Co- localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:22351768, PubMed:18981471). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720) Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). |
| Tissue Location | [Isoform 1]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAD1L1 is a component of the mitotic spindle-assemblycheckpoint that prevents the onset of anaphase until all chromosomeare properly aligned at the metaphase plate. MAD1L1 functions as ahomodimer and interacts with MAD2L1. MAD1L1 may play a role in cellcycle control and tumor suppression. Three transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Guo, Y., et al. J. Med. Genet. 47(9):616-622(2010)Wang, H.B., et al. J. Gastrointest. Surg. 14(8):1227-1234(2010)Hewitt, L., et al. J. Cell Biol. 190(1):25-34(2010)Ge, Z., et al. FASEB J. 24(2):579-586(2010)
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