|Other Names||Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1, SFRP2, FRP2, SARP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.|
|Tissue Location||Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.|
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This gene encodes a member of the SFRP family thatcontains a cysteine-rich domain homologous to the putativeWnt-binding site of Frizzled proteins. SFRPs act as solublemodulators of Wnt signaling. Methylation of this gene is apotential marker for the presence of colorectal cancer. [providedby RefSeq].
von Marschall, Z., et al. Biochem. Biophys. Res. Commun. 400(3):299-304(2010)Pehlivan, S., et al. Cancer Genet. Cytogenet. 201(2):128-132(2010)Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)Yamamura, S., et al. Mol. Cancer Ther. 9(6):1680-1687(2010)Forsman, H., et al. BMC Cell Biol. 11, 52 (2010) :
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