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RPL11 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P62913
Clone Names 100318031
Additional Information
Gene ID 6135
Other Names 60S ribosomal protein L11, CLL-associated antigen KW-12, RPL11
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPL11
Function Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:32669547, PubMed:19191325). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:32669547, PubMed:19191325). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:32669547, PubMed:19191325). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:32669547, PubMed:19191325). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).
Cellular Location Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q9CXW4}
Research Areas
Citations (0)
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Background

Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L5P family of ribosomal proteins. It is located in thecytoplasm. The protein probably associates with the 5S rRNA.Alternative splice variants encoding different isoforms may exist,but they have not been fully characterized. As is typical for genesencoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome. [provided byRefSeq].

References

Sun, X.X., et al. J. Biol. Chem. 285(33):25812-25821(2010)Konno, Y., et al. Haematologica 95(8):1293-1299(2010)Dai, M.S., et al. J. Biol. Chem. 285(17):12587-12594(2010)Holzel, M., et al. J. Biol. Chem. 285(9):6364-6370(2010)Quarello, P., et al. Haematologica 95(2):206-213(2010)

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$ 277.78
Cat# BP12353a
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