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UGT2B15 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P54855
Clone Names 100311205
Additional Information
Gene ID 7366
Other Names UDP-glucuronosyltransferase 2B15, UDPGT 2B15, HLUG4, UDP-glucuronosyltransferase 2B8, UDPGT 2B8, UDPGTh-3, UGT2B15, UGT2B8
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGT2B15 (HGNC:12546)
Function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:7835232, PubMed:9295060, PubMed:16595710, PubMed:18719240, PubMed:23288867). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4- hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in many tissues. Present in liver, prostate and testis.
Research Areas
Citations (0)
citation

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Background

The UGTs are of major importance in the conjugation andsubsequent elimination of potentially toxic xenobiotics andendogenous compounds. UGT2B8 demonstrates reactivity with estriol.See UGT2B4 (MIM 600067).

References

Yong, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):537-546(2010)Sun, C., et al. Hum. Mutat. 31(1):99-107(2010)Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)He, X., et al. Br J Clin Pharmacol 68(5):721-730(2009)Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009) :

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$ 277.78
Cat# BP12375c
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